To everything there is a season. In an analysis of a Larry Sabato analysis of the potential for Republicans to gain Congress and the Senate this year, and in which Sabato states that this cycle will the Republicans' to lose, Ed Morrissey notes that Sabato poins to the the potential of a GOP big win. That is, if the GOP keeps the focus on Obamacare and conservatives don't shoot the GOP in the foot.
To the latter point, Morrissey sums up the situation perfectly:
In this case, we’re better off getting Republicans elected rather than spending this election in a purification effort. Right now, the majority has got to be the priority.